What is the Entourage Effect?

The entourage effect is a phenomenon in which varying compounds within cannabis interact with each other in the human body, producing a synergistic, therapeutic effect. The entourage effect can only occur when there are multiple cannabinoids at play, not just one compound in isolation. Many cannabis consumers may be most focused on the two main cannabinoids that offer cognitive and medical benefits, CBD and THC, but other cannabinoids and aromatic compounds (terpenes) should not be underestimated or ignored. 

Research has shown that the collaborative effects of terpenes and various cannabinoids enhance each other’s effects. CBN, CBC, CBG, aromatic compounds terpenes, and dozens of other elements can come together in unique combinations to create a more powerful experience. By understanding the delicate balance of the entourage effect, cannabis consumers can take advantage of the full potential of cannabis. After all, everyone has different preferences when it comes to their expectations of medicinal or recreational weed. By staying up-to-date on the complexity and versatility of cannabis, you can invest your time and money into the best products that meet your exact expectations and taste. 

Whether you are new to cannabis or open to more intense experiences as a weed connoisseur, you can find a wide selection of quality, lab-researched cannabis products here at Canna Culture in San Jose. Though we primarily serve the residents of San Jose, we offer free delivery services within a 20-mile radius, providing the best in flower, pre-rolls, edibles, accessories, and more. Feel free to browse with our online store, and we will work to get your products to your door as quickly as possible. 

To get in touch with us for any questions you have about our products or dispensary, call (408) 264-7877 or use our inquiry form, and we will get back to you as soon as we can. 

The Endocannabinoid System 

The reason why cannabis affects us at all is due to our built-in endocannabinoid system (ECS) within the brain. This is a network of chemical receptors that can process the compounds in cannabis. Even without cannabis, the brain naturally produces chemicals similar to cannabis compounds called endocannabinoids that serve to regulate certain bodily processes. This system primarily influences the connections between neurons in the brain, affecting functions such as memory and learning, metabolism, development, and the nervous system as a whole. (2) 

The two most important cannabis receptors to know are CB1 and CB2, each capable of interpreting different chemical signals. CB1 can activate the psychoactive effects of THC and allow users to reap the pain-relieving benefits available within cannabis. Most CB1 receptors are found within the brain, fat cells, liver cells, and skeletal muscles. CB2 receptors, on the other hand, can facilitate anti-inflammatory effects without inducing a psychoactive effect in the user. These receptors are most common within the brain, spinal cord, and the body’s immune cells. 

Both the CB1 and CB2 receptors work together to metabolize cannabinoids, providing the body and mind effects characteristic of certain strains. The unique chemical profile of each cannabis product is why some products produce more of a “body high” that leaves you more relaxed, whereas others may leave you feeling more alert and able to socialize without the bedtime buzz. 

The Unique Effects of Lesser-Known Cannabinoids 

Though THC and CBD often take the spotlight when it comes to those looking for their ideal experience, here is what some of the other cannabinoids and terpenes can accomplish


CBG, short for cannabigerol, is a cannabinoid that aids in the alleviation of anxiety, inflammation related to infection, nausea, and even cancer symptoms. Research finds that it can reduce pressure within the eye (intraocular pressure), act as an antioxidant, and combat the development of tumors. It is unique in the sense that it exhibits neuroprotective qualities, appetite-stimulating effects, and skin-rejuvenation benefits. (3) As a non-psychoactive compound, CBG can be found in many CBD-dominant products and hemp concentrates. 


THCV, also called tetrahydrocannabivarin, has recently been studied for its ability to treat obesity and diabetes. Many users seek out cannabis with THCV as a means to prevent the onset of the “munchies” since it can act as an appetite suppressant. In addition, it serves to boost metabolism and improve glycemic control (blood sugar levels). (4) 


THCa is a raw form of THC without the same psychoactive effects. Though it converts to THC rather easily with exposure to room temperature, some THCa within cannabis is preserved and serves as a neuroprotective, anti-seizure compound. It is also highly capable as an aid to relieving symptoms of Parkinson’s and multiple sclerosis. 


Cannabinol, or CBN, is only available in trace amounts within the cannabis plant because it is mostly a byproduct of degraded THC. Just like other cannabinoids, it has the potential to behave as an anti-inflammatory agent and an appetite stimulant. It can also induce sleep. Some scientific evidence suggests that CBN has a unique ability to help users gain better control over their ADHD symptoms. (5) 


Delta-8-THC is another trace cannabinoid that promotes a limited psychoactive effect, but it reduces the likelihood that consumers will experience anxiety and paranoia. It is often sought out by users seeking to take advantage of the medicinal aspects of cannabis without the intense high of THC. It is most well-known as an appetite stimulant and nausea-reducing compound


Terpenes are responsible for the earthy and fruity flavorings within cannabis and other plants. Cannabis contains about 400 different terpenes, each equipped with varying elements that contribute to cannabinoid effectiveness. Studies have shown that some of the most helpful terpenes can fight against depression and anxiety. Others have antimicrobial and antifungal properties. 

Cannabis Delivery

With knowledge of the distinctive qualities of each of these cannabinoids, you can seek out high-quality cannabis with them in mind. At Canna Culture, we offer a range of products for you to experience the entourage effect for yourself with our extensive online menu

  • We deliver to multiple areas of Santa Clara County, including Mountain View, Los Gatos, Cupertino, Sunnyvale, and the surrounding areas. 
  • We offer free delivery within 20 miles of our dispensary location and operate from 9 am to 9 pm every day! 
  • To qualify for delivery, you will need to order at least $100 worth of our products 
  • Depending on the time of day, you should expect to receive your order the same day
  • For those who want to avoid delivery fees, we also allow curbside pickup
  • If you are a loyal customer of Canna Culture, consider joining our VIP program for exclusive specials and event details. 

If you are curious about any of our available products, check out our FAQ page to learn more about what you need to know. We pride ourselves on being helpful and informative to all of our clients, regardless of their previous experiences with cannabis. 

Canna Culture’s VIP Rewards Program 

Canna Culture’s VIP program is designated for our most loyal customers to get a 2% return on every dollar spent on one of our products. As a long-time cannabis enjoyer, this can save you a significant amount over time. Not only that but if you introduce Canna Culture to a friend, they will get a $2 pre-roll with any purchase. As a member of our dispensary, you will be the first to get information about our events, BOGO sales, and other discounts. 

Stay In Touch

Follow our San Jose dispensary on Facebook, Twitter, Instagram, or TikTok to stay in the Canna Culture loop. Our team of budtenders will keep you updated on the latest flower, concentrates, edibles, pre-rolls, and more! To get more in-depth information on our products, feel free to browse through our website’s blog. We strive to provide our regular customers with accurate and informative posts on cannabis and recent happenings within the industry. 

Weed for Delivery in San Jose

To find out more about our same-day delivery service or any of our online products, give us a call at (408) 264-7877 and our staff will provide you with the guidance you need to find the perfect product for your cannabis needs. Whether you are a beginner or have detailed questions, we help all 21+ prospective customers with professionalism and a welcoming, positive attitude. 


Can you experience the entourage effect with CBD products? 

If it is a CBD-only product, you will not experience the benefits of the entourage effect. However, if you choose a full or broad-spectrum product with multiple cannabinoids, then they may interact chemically and enhance the effects of CBD. Products that incorporate components of the entire cannabis flower can also help. 

Is the entourage effect psychoactive? 

The entourage effect is not necessarily a psychoactive process. Non-psychoactive compounds can interact with each other and enhance effects like pain and nausea relief, for example. 


  1. Skaper SD, Di Marzo V. Endocannabinoids in nervous system health and disease: the big picture in a nutshell. Philosophical Transactions of the Royal Society B: Biological Sciences. 2012;367(1607):3193-3200. doi:https://doi.org/10.1098/rstb.2012.0313 
  2. An D, Peigneur S, Hendrickx LA, Tytgat J. Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products. International Journal of Molecular Sciences. 2020;21(14):5064. doi:https://doi.org/10.3390/ijms21145064 
  3. Calapai F, Cardia L, Esposito E, et al. Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives. Evidence-Based Complementary and Alternative Medicine: eCAM. 2022;2022:3336516. doi:https://doi.org/10.1155/2022/3336516 
  4. Jadoon KA, Ratcliffe SH, Barrett DA, et al. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care. 2016;39(10):1777-1786. doi:https://doi.org/10.2337/dc16-0650 
  5. Hergenrather JY, Aviram J, Vysotski Y, Campisi-Pinto S, Lewitus GM, Meiri D. Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients. Rambam Maimonides Medical Journal. 2020;11(1). doi:https://doi.org/10.5041/RMMJ.10384 
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